Our laboratory is based at the Living Systems Institute at the University of Exeter. We use advanced imaging approaches to address a variety of biophysical questions. Imaging in general, and fluorescence imaging in particular, is playing an increasingly important role in Biophysics and Biology. Our ability to come up with mechanistic descriptions of living systems depends to a large extent on our ability to see the components of a cell, an organism, etc. Our laboratory therefore applies and develops state-of-the-art microscopy methods to improve our understanding of the world around us.
Our work is directly motivated by the goal to improve our knowledge of the biophysics and physiology of specific biological systems. Our primary focus is on cardiac muscle biophysics with a unifying theme to elucidate the relationship between nanoscale cell morphology and calcium signalling.
Our understanding of how biological systems work is dependent on the ability to see these systems, ideally with a resolution that approaches subcellular and even molecular scales. This has become possible by rapid advances in fluorescence imaging. The holy grail of advanced imaging is fully quantitative microscopy, that allows us to count molecules in situ, fully spatially resolved, so that we can distinguish different populations, provide molecular statistics, and similar quantitative measures that link form and function. Such quantitative molecular imaging is now becoming a practical reality with the latest imaging modalities.