Current Opportunities - PhD student positions starting in 2021
We currently have two fully funded PhD openings to work with us on state-of-the-art imaging approaches in the Living Systems Institute. The LSI provides an exciting interdisciplinary environment bringing together leaders in Biology, Physics, Medicine and Mathematics.
The first project Investigation of protein-protein interactions that regulate RNA processing in the nucleus using novel super-resolution microscopy uses new imaging capabilities to address a major question on RNA regulation, topical with the advent of mRNA vaccines.
The second project 3D super-resolution probing of DNA nanostructures using deep learning combines super-resolution imaging, DNA nanotechnology, nanoscale mechanics and machine learning for a state-of-the-art investigation into how we can design and use new nanoscale structure.
Please get in touch for inquiries.
Our laboratory is based at the Living Systems Institute at the University of Exeter. We use advanced imaging approaches to address a variety of biophysical questions. Imaging in general, and fluorescence imaging in particular, is playing an increasingly important role in Biophysics and Biology. Our ability to come up with mechanistic descriptions of living systems depends to a large extent on our ability to see the components of a cell, an organism, etc. Our laboratory therefore applies and develops state-of-the-art microscopy methods to improve our understanding of the world around us.
Our work is directly motivated by the goal to improve our knowledge of the biophysics and physiology of specific biological systems. Our primary focus is on cardiac muscle biophysics with a unifying theme to elucidate the relationship between nanoscale cell morphology and calcium signalling.
Our understanding of how biological systems work is dependent on the ability to see these systems, ideally with a resolution that approaches subcellular and even molecular scales. This has become possible by rapid advances in fluorescence imaging. The holy grail of advanced imaging is fully quantitative microscopy, that allows us to count molecules in situ, fully spatially resolved, so that we can distinguish different populations, provide molecular statistics, and similar quantitative measures that link form and function. Such quantitative molecular imaging is now becoming a practical reality with the latest imaging modalities.