Openings

LSI Our laboratory is based at the Living Systems Institute at the University of Exeter. The new institute provides an exciting interdisciplinary environment bringing together leaders in Biology, Physics, Medicine and Mathematics.

EPSRC funded PhD to combine nanometer resolution imaging and single molecule plasmonic sensors

An exiting PhD opening for a September 2019 start.

Deadline: 7 Jan 2019
Title: DNA scaffolded gold nanoparticles for improved single‐molecule biosensing
Funding: RCUK level Fees & Scholarship
Apply: via U Exeter website
Important Application hints: On the page linked above select the link named 'Click here to submit an application for Biomedical Physics' and name our project in your application.

This new PhD opportunity is a collaboration between the Soeller lab and the Vollmer lab at the Living Systems Institute.

Au NP DNA Origami

In this project we will use optical super-resolution imaging, DNA nanotechnology and single-molecule sensors to make a new sensing modality with extreme sensitivity. For this project we are joining forces with the Vollmer laboratory who are experts in plasmonic single-molecule sensors.

Full Project Details

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PhD project on new super-resolution methods applied to RNA biology (funded)

A project with industrial partner Bio-Techne

Deadline: 26 Nov 2018
Title: Illuminating mechanisms of RNA transcription by novel optical super-resolution imaging approaches
Funding: Fees & Scholarship at RCUK levels, for eligible domestic and EU students
Start: January 2019 or later - flexible - we want to find the right candidate
Apply: Online via Exeter Website

We have opened applications for this PhD project, interested candidates are highly encouraged to contact the supervisors, Christian Soeller or Steve West, to make enquiries and express their interest.

Pol II super-resolution imaging

We are inviting applications for a fully-funded PhD studentship to commence in January 2019 or as soon as possible thereafter, to be held at the Living Systems Institute at its Streatham Campus. For eligible students the studentship will cover UK/EU tuition fees plus an annual tax-free stipend.

For this project we have partnered with Bio-Techne, a leading developer of high quality reagents and assay systems for biomedical researchers and clinical research laboratories.

Full Project Details

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MRC funded PhD on Protein Cluster Biophysics, Stem Cell Repair and Super-Resolution Imaging

Deadline: 23rd November 2018
Title: Modifying protein clustering as a novel repair strategy in heart failure
Funding: Fees & Scholarship at RCUK levels, for eligible domestic and EU students
Start: September 2019
Apply: Online Application via Exeter Website

In this project the focus will be on repair strategies for cells in failing hearts. New insight by the participating laboratories suggests that the modulation of protein clustering can boost cellular function and support tissue repair in the heart. We will test the new approaches in stem cell derived models of cardiomyocytes.

RyR clusters in super-resolution detail

Figure. Magnified views of matching confocal and super-resolution images showing ryanodine receptor (RyR) clusters in the surface membrane of a cardiac myocyte. Note the small clusters and likely single RyRs [indicated by arrowheads] that are undetectable in the diffraction-limited data. (E) To quantify cluster sizes (in RyRs/cluster), quasi-crystallinearrangement of RyRs on a 30 × 30 nm grid was used.

Full Project Details

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BBSRC funded PhD on Protein Cluster Biophysics and Super-Resolution Imaging

Deadline: 3rd December 2018
Title: Effects of clustering and phosphorylation on nanoscale receptor signalling
Funding: BBSRC, Fees & Scholarship at RCUK levels, for eligible domestic and EU students
Start: September 2019
Apply: Online Application via Exeter Website

We intend to focus on understanding the basis of the dependence of protein excitability on the protein clustering properties. For this we will combine quantitative imaging via super-resolution (Soeller lab) and correlation imaging (Scholpp lab) with new biological insights following the discovery of the role of the protein myospryn for RyR clustering.

RyR cluster models

Figure. Emerging view of ryanodine recptor (RyR) arrangement within clusters. (A) The classic model of a regular arrangement of RyRs. (B) The revised model based on tomographic EM and our new DNA-PAINT super-resolution data proposing looser arrangement of RyRs. Adapted from Jayasinghe et al. (2018).

Full Project Details

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EPSRC funded PhD to combine nanometer resolution imaging and single molecule plasmonic sensors

An exiting PhD opening for a September 2019 start. Applications will open very soon! Please get in touch.

Deadline: April 2019
Title: A DNA-metal nanoparticle metamaterial for improved single-molecule biosensing
Funding: EPSRC Metamaterials CDT, RCUK level Fees & Scholarship, for eligible domestic and EU students
Apply: Online

This new PhD opportunity is a collaboration between the Soeller lab and the Vollmer lab at the Living Systems Institute.

Au NP DNA Origami

In this project we will use optical super-resolution imaging, DNA nanotechnology and single-molecule sensors to make a new sensing modality with extreme sensitivity. For this project we are joining forces with the Vollmer laboratory who are experts in plasmonic single-molecule sensors.

Full Project Details

See here for full project details...